Genmab and Jacobi Pharmaceutical join forces with AbbVie
Genmab and Jacobi Pharmaceutical join forces with AbbVie
… AbbVie expands its oncology business through two new strategic partnerships …


Genmab and Jacobio Pharmaceuticals Join Forces With AbbVie

John G. Baresky

AbbVie (NYSE: ABBV) is wasting no time in making the most out of 2020. Following the FDA approval of their Women’s Healthcare breakthrough drug therapy for uterine fibroids, Oriahnn (elagolix, estradiol and norethindrone acetate capsules; elagolix capsules), and completion of their $63 billion acquisition of Allergan, AbbVie has immediately followed through by signing deals with Genmab (NASDAQ: GMAB) and Jacobio Pharmaceuticals.

Jacobi Pharmaceuticals is a venture-funded biotherapy organization

SHP2 targeting oncology therapy

Jacboio’s two small-molecule SHP2 early-stage pipeline candidates are:

AbbVie will have an exclusive license to these two molecules and Jacobio will orchestrate the ongoing clinical trials of each that AbbVie will fund. AbbVie will have global commercialization and marketing rights to the products if they suitably progress and complete regulatory approval processes. Their agreement also features an option for Jacobio to develop and market the SHP2 candidates in mainland China, Hong Kong and Macau on their own.

Genmab is purely focused on developing innovative oncology treatment therapies

AbbVie is committing $750 million to help fund Genmab’s oncology antibody initiatives and will provide up to $3.15 billion depending on the progress towards specific development goals along the way. There are three pipeline candidates featured in the agreement:

  • DuoBody (CD3x5T4)
  • DuoHexaBody (CD37)
  • Pcoritamab (DuoBody-CD3xCD20)

The three drugs are immune response therapies. By deploying AbbVie’s antibody-drug conjugate (ADC) technology within their formulations, the therapies will bypass healthy cells on their way to delivering therapeutic toxins to cancer cells that disable them.

Funding, clinical and commercial experience are pivotal reasons to partner with AbbVie

AbbVie has the resources to drive market access

AbbVie is a new organization following its acquisition of Allergan

Mile White was responsible for the very creation of AbbVie through dividing the original Abbott Laboratories into two different companies, AbbVie and Abbott. AbbVie is highly motivated to transform its enterprise through exponential growth to pay down its debt from acquiring Allergan and replace revenues from its multi-billion-dollar blockbuster immunotherapy Humira as it approaches the end of its patent protection in 2023.

Based in North Chicago, Illinois, AbbVie generated over $33.5 billion in annual sales during 2019. Following its ongoing success with new product introductions, strategic partnerships like those with Genmab and Jacobio plus the addition of Allergan, AbbVie is competitively well-positioned to move forward into the new decade.

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